Ovime se sprečava hiperkeratinizacija ovih ćelija koja može dovesti do blokade. Retinol, oblik vitamina A, ima slično samo blaže dejstvo i koristi se u brojnim komercijalnim ovlaživačima i ostalim topijskim proizvodima. Delotvorni topijski retinoidi su u upotrebi preko thirty godina ali su dostupni samo na recept i nisu u širokoj upotrebi k
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